资 源 简 介
nsilk is a tool to spot protein complexes topology from mass spectrometry data of cross-linked proteins.
It is in early development stage and currently has been tested on a limited data set coming from FT-ICR spectrometer (and some ESI/QTOF data).
The entire project started in 2006 has been algorithmically described in this paper by Maiolica et al.:
Mol Cell Proteomics. 2007 Dec;6(12):2200-11. Epub 2007 Oct 5
Although the original implementation helped in topology identification, it was a bit to too clumsy. We"ve decided to rewrite it from scratch as a stand-alone application (based on OMSSA), named silk.
Soon we"ve realized that there may be some issues by relying on external search algorithm. We"ve decided to start once again from scratch with nsilk.
We could biochemically validate most of the int
