streamtr

STREAM - Static Thermodynamic REgulAtory Model of transcription, is a bioinformatics application for researchers, who want to model the transcriptional regulation of a specific gene and predict its transcriptional output in different situations. Introduction STREAM is the first publicly available framework for modeling, visualizing, and predicting the regulation of the transcription rate of a target gene. Understanding transcriptional regulation of a gene in detail is a crucial step towards uncovering and ultimately utilizing the regulatory grammar of the genome. Modeling transcriptional regulation using thermodynamic equations has become an increasingly important approach towards this goal. Given the concentration of a set of transcription factors as well as the transcription factor binding