comrad

Both paired end whole transcriptome shotgun sequencing (RNA-Seq), and paired end Whole Genome Shotgun Sequencing (WGSS), can be used to discover rearrangements in tumour genomes. Comrad is a novel algorithmic framework for the integrated analysis of RNA-Seq and WGSS data for the purposes of discovering genomic rearrangements and aberrant transcripts. The Comrad framework leverages the advantages of both RNA-Seq and WGSS data, providing accurate classication of rearrangements as expressed or not expressed and accurate classication of the genomic or non-genomic origin of aberrant transcripts. A major benet of Comrad is its ability to accurately identify aberrant transcripts and associated rearrangements using low coverage genome data. As a result, a Comrad analysis can be performed at a cost comparable to that of two RNA-Seq experiments, signicantly lower than an analysis requiring high coverage genome data. Manual 请点击左侧文件开始预览 ！预览只提供20%的代码片段，完整代码需下载后查看 加载中 侵权举报