资 源 简 介
GenomeSmasher is a set of tools used to create diploid fasta files with containing snps, indels, duplications, deletions, and translocations. These FASTA files can then be used in conjunction with next-gen sequencing simulators to artificially create sequencing experiments. The utitlity of these tools are to assess the performance and reliability of data analysis in next-gen sequencing pipelines.
We also provide 2 scripts to help prepare input files for GenomeSmasher
1. SNP\_mutator\_v2.pl
1. SV\_generator.sh
Input parameters to the script
* "refgenome_dir" => Path to the genome directory (Each chromosome must have separate fasta file Ex: Chr1.fa).
* "input_vcf_like’ => Structural Variants to be implemented must be described in the VCF like file(Fist 8 columns mandatory).
* "process_dir" => Path to
