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A Python programming interface to EGS5 and a pythonic Monte Carlo simulation environment for radiation transport calculations has been developed, called PyEGS5. With binding to Python, PyEGS5 can be used in a scripting and interpreted way, while maintaining the efficiency of the Fortran binary code. As a powerful modern programming language, Python brings to EGS5 many advanced programming features and resources, with which users can create full featured Monte Carlo simulation applications. PyEGS5 could be a very useful in medical physics research, fast-prototyping of medical physics devices and teaching Monte Carlo simulation to medical physics students. Please see the wiki page!