资 源 简 介
BUGSModelLibrary is a prototype PKPD model library for use with WinBUGS 1.4.3. The current version includes:
* Specific linear compartmental models:
* One compartment model with first order absorption
* Two compartment model with elimination from and first order absorption into central compartment
* General linear compartmental model described by a matrix exponential
* General compartmental model described by a system of first order ODEs
The models and data format are based on NONMEM/NMTRAN/PREDPP conventions including:
* Recursive calculation of model predictions
* This permits piecewise constant covariate values
* Bolus or constant rate inputs into any compartment
* Handles single dose, multiple dose and steady-state dosing histories
* Implemented NMTRAN data items include:
* TIME, EVID, CMT, AMT, RATE, ADDL, II, SS
The library provides BUGS language functions that calculate amounts in each compartment. BUGSModelLibrary is an active, open-source project of Metrum Resea
